Publications & Creative Works

Selected Publications

Alcala Zuniga D, Torres E, Vargas M, Maldonado O, Benavides O, Manojkumar A, de la Garza R, Davila N, Perez I, Hernandez Martinez A; Roy D, Lopez-Juarez A, Zarei M, Baker K, Gil M, Rodrigo H, de Erausquin G, Roy, U. Enriched Environment Contributes to the Recovery from Neurotoxin-induced Parkinson’s Disease Pathology. Mol Neurobiol
Xu C, Xiao D, Su BB, Saveron JM, Gamez D, Navia RO, Wang N, Roy U, Adjeroh DA, Wang K; Alzheimer and Disease Neuroimaging Initiative. Association of APOE gene with longitudinal changes of CSF amyloid beta and tau levels in Alzheimer’s disease: racial differences. Neurol Sci. 2023 Sep 28. doi: 10.1007/s10072-023-07076-1.PMID: 37759100.
Maestre G, Carrillo M, … Deepa R, Roy U, ..; African Dementia Consortium. The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs. Alzheimers Dement. 2023 Mar 11. doi: 10.1002/alz.13025. Epub ahead of print. PMID: 36905253.
Garces A , Martinez B, De La Garza R, Roy D, Vallee K-A, Fields JA, Moore DJ., Rodrigo H, Roy U. Differential Expression of Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in Alzheimer’s Disease and HIV-1 Associated Neurocognitive Disorders. Sci Rep (Nature),2023 (PMID: 36841839).
Garcia CR, Rad AT, Saeedinejad F, Manojkumar A, Roy D, Rodrigo H, Chew SA, Rahman Z, Nieh MP, Roy U. Effect of drug-to-lipid ratio on nanodisc-based tenofovir drug delivery to the brain for HIV-1 infection. Nanomedicine (Lond). 2022 Jun;17(13):959-978. PMID: 35642549.
Dethe MR, A P, Ahmed H, Agrawal M, Roy U, Alexander A. PCL-PEG copolymer based injectable thermosensitive hydrogels. J Control Release. 2022 Mar;343:217-236. doi: 10.1016/j.jconrel.2022.01.035. Epub 2022 Jan 25. PMID: 35090961.
Pial MMH, Tomitaka A, Pala N, Roy U. Implantable Devices for the Treatment of Breast Cancer. J Nanotheranostics. 2022 Mar;3(1):19-38. doi: 10.3390/jnt3010003. Epub 2022 Feb 9. PMID: 37600442; PMCID: PMC10438892.
Kamkwalala AR, Garg A, Roy U, Matthews A, Castillo-Mancilla J, Lake JE, Sebastiani G, Yin MT, Brown TT, Kamer A, Jabs DA, Ellis RJ, Boffito M, Greene M, Schmalze S, Siegler E, Erlandson KM, Moore D. Current Considerations for Clinical Management and Care of People with HIV: Findings from the 11th Annual International HIV & Aging Workshop. AIDS Res Hum Retroviruses. 2021 Aug 18. doi: 10.1089/AID.2021.0059. Epub ahead of print. PMID: 34405689.
Tomitaka A, Takemura Y, Huang Z, Roy U, Nair M. Magnetoliposomes in Controlled-Release Drug Delivery Systems. Crit Rev Biomed Eng 2019;47(6):495-505. PMID: 32421974
R. De La Garza, H Rodrigo, F Fernandez, U Roy. The Increase of HIV-1 Infection, Neurocognitive Impairment, and Type 2 Diabetes in The Rio Grande Valley. Curr HIV Res. 2019. PMID: 31663481.
P Malhotra, P Haslett, B Sherry, D Shepp, P Barber, J Abshier, U Roy, and H Schmidtmayerova. Increased Plasma Levels of the TH2 chemokine CCL18 associated with low CD4+ T cell counts in HIV-1-infected Patients with a Suppressed Viral Load. Sci Rep. (Nature), 2019 Apr 12;9(1):5963.PMID: 30979916.
Gerlach SL, Chandra PK, Upal Roy, Gunasekera S, et al . The Membrane-Active Phytopeptide Cycloviolacin O2 Simultaneously Targets HIV-1-infected Cells and Infectious Viral Particles to Potentiate the Efficacy of Antiretroviral Drugs. Medicines (Basel). 2019 Feb 28;6(1). PMID: 30823453.
Upal Roy, Vadym Drozd, Andriy Durygin, Jesse Rodriguez, Paul Barber, Venkata Atluri, Xiaohua Liu, Thomas G Voss, Surendra Saxena, Madhavan Nair (2018). Characterization of Nanodiamond-based anti-HIV drug Delivery to the Brain. Sci Rep. (Nature), 2018 Jan 25;8(1):1603. doi: 10.1038/s41598-017-16703-9. PMID: 29371638. (Corresponding author).
A Kaushik, R.D. Jayant, R Nikkhah-Moshaie, V Bhardwaj , Upal Roy, Z Huang, A Ruiz, A Yndart, V Atluri, N El-Hage, K Khalili, M Nair. Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers. Sci Rep (Nature), 2016 May 4;6:25309. (PMCID: PMC5785470).
Upal Roy, J Rodríguez, P Barber, J Neves, B Sarmento, M Nair. (2015). The Potential of HIV-1 Nanotherapeutics: from in vitro studies to clinical trials. Nanomedicine (London). 2015; 10(24):3597-609. (PMID: 26400459) (Corresponding author)
Upal Roy, P Barber, YC Tse-Dinh, E Batrakova, D Mondal, M Nair. (2015). Role of MRP transporters in regulating antimicrobial drug inefficacy and oxidative stress-induced pathogenesis during HIV-1 and TB infections. Front. Microbiol.6:948. doi: 10.3389/fmicb.2015.00948. (PMID:26441882) (Corresponding author)
Upal Roy, H Ding, S P Kanthikeel, A Raymond, VAtluri, A Yndart, E M. Kaftanovskaya, E Batrakova, M Agudelo, M Nair.2015. Preparation and Characterization of Anti-HIV Nano drug Targeted to Microfold cell of Gut-associated lymphoid Tissue (GALT). International Journal of Nanomedicine. 10:5819-35. doi: 10.2147/IJN.S68348. (PMID: 26425084). (Corresponding author) Video abstract: https://www.youtube.com/watch?v=XrMY98sT4Nc
Upal Roy, VS Atluri, M Agudelo, A Yndart, Z Huang and M Nair (2015). DJ1 Expression Downregulates in Neuroblastoma Cells (SK-N-MC) Chronically Exposed to HIV-1 and Cocaine. Front. Microbiol. 6:749. doi: 10.3389/fmicb.2015.00749. (PMID: 26284039). (Corresponding author)
A.D Raymond, P Diaz, S Chevelon, M Agudelo, A Yndart-Arias, H Ding, A Kaushik, R D. Jayant, Upal Roy, S. Pilakka-Kantakeel, and M.P Nair.2015 Microglia-derived HIV Nef+ exosome (exNef) impairment of the blood-brain-barrier is treatable by nanomedicine-based delivery of Nef peptides. J Neurovirol. . (PMID:26631079)
T Samikkannu, KV Rao, S Pilakka Kanthikeel, V Atluri Subba Rao, M Agudelo, Upal Roy, MP Nair. 2014. Immunoneuropathogenesis of HIV-1 clades B and C: Role of redox expression and thiol modification. Free Radic Biol Med.69:136-44. (PMID: 24480751)
Upal Roy, C. Bulot, T. Hazari, A. Verma, K H zu Bentrup, D Mondal. 2013. Specific increase in P-gp (ABCB1) expression and drug-efflux function in human brain endothelial cells following concomitant exposure to HIV-1 and saquinavir. PLOS one. Oct 3;8(10):e75374. (PMID: 24098380) (Corresponding author)
SL Gerlach, M Yeshak, U Göransson, Upal Roy, R Izadpanah, D Mondal. 2013. Cycloviolacin O2 (CyO2) suppresses productive infection and augments the antiviral efficacy of nelfinavir in HIV-1 infected monocytic cells. Biopolymers. 100(5):471-479. (PMID: 23897405)
N Gautam, Upal Roy, S Balkundi, P Puligujja, D Guo, N Smith, XM Liu, B Lamberty, B Morsey, H Fox, J McMillan, H E. Gendelman, Yazen Alnouti 2013. Preclinical Pharmacokinetics and Tissue Distribution of Long-Acting Nanoformulated Antiretroviral Therapy. Antimicrobial agents and chemotherapy 57 (7), 3110-3120. (PMID: 23612193).
Upal Roy, J McMillan, Y Alnouti, N Gautum, N Smith, S Balkundi, P Dash, S Gorantla, A Martinez-Skinner, J Meza, G Kanmogne, S Swindells, S.M. Cohen, R.L Mosley, L Poluektova , H.E. Gendelman. 2012. Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice. J Infectious Disease. 206(10):1577-88. (PMID: 22811299).
P. Dash, H.E. Gendelman,Upal Roy, S. Balkundi, T.Gutti, J.Knibbe, E. Makarov, N. Smith, Y. Alnouti, R. L. Mosley, H.A. Gelbard, J. McMillan, S. Gorantla, and L. Poluektova. 2012.Long-acting Nanoformulated Protease Inhibitors Show Potent Antiretroviral Responses in HIV-1 Infected Humanized Mice. AIDS. 26(17):2135-44. (PMID: 22824628)
G.D. Kanmogne, S. Singh, Upal Roy, X. Liu, J McMillan,S Gorantla, S Balkundi, N Smith, Y Alnouti, N Gautam, Y Zhou, L Poluektova, A Kabanov, T Bronich and H E.Gendelman.2012. Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells. International Journal of Nanomedicine 7.1-16. (PMID: 22661891)
S Balkundi, A.S. Nowacek, R.S. Veerubhotla, H Chen, A Martinez-Skinner, Upal Roy, RL Mosley, G Kanmogne, X Liu, A.V. Kabanov, T Bronich, J McMillan, H.E. Gendelman.2011. Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. International Journal of Nanomedicine.6:3393-404. (PMID: 22267924)
J Huang, N Gautam, SP Bathena, Upal Roy, J McMillan, HE Gendelman, Y Alnouti.2011. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. Journal of Chromatography B 879(23):2332-8. (PMID: 21752731)
TZ Nazari-Shafti, E Freisinger, Upal Roy, CT Bulot, C Senst, CL Dupin, AE Chaffin, SK Srivastava, D Mondal, EU Alt, R Izadpanah. 2011. Mesenchymal stem cell-derived hematopoietic cells are permissive to HIV-1 infection. Retrovirology.12;8(1):3. (Article is considered as ‘Highly accessed’ relative to age) (PMID: 21226936)
S Balkundi, AS Nowacek, Upal Roy, A Martinez-Skinner, J McMillan, H. E. Gendelman.2010. Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs. Journal of Visual Experiments (46):pii 2460.doi.10.3791/2460.(PMID: 21178968)
AS Nowacek , S Balkundi , J McMillan , Upal Roy , A Martinez-Skinner , RL Mosley , G Kanmogne , AV Kabanov , T Bronich , HE Gendelman . 2011. Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release, and antiviral activities in human monocyte-derived macrophages. Journal of Control Release. 150(2):204-11.(PMID: 21108978)
Upal Roy , G Chakravarty , K Honer Zu Bentrup , D Mondal. 2009. Montelukast is a potent and durable inhibitor of multidrug resistance protein 2-mediated efflux of taxol and saquinavir. Biological & pharmaceutical bulletin32(12):2002-9. (PMID: 19952419)
Upal Roy, S A. Simpson, D Mondal, S Eloby-Childress, E L. Winsor, M A. Beilke. 2008. Up-regulation of HTLV-1 and HTLV-2 expression by HIV-1 in vitro. Journal of Medical Virology. 80(3):494-500. (PMID: 18205225)
M. A. Eilers, Upal Roy and D. Mondal. 2008.MRP (ABCC) transporters-mediated efflux of anti-HIV drugs, saquinavir, and zidovudine, from human endothelial cells. Experimental Biology and Medicine. (Maywood). 233(9).1149-1160.(PMID: 18535159).
R Dixit, Upal Roy, S. Patole, Y S. Shouche.2008. Molecular and Phylogenetic analysis of a novel family of fibrinogen-related proteins from mosquito Aedes albopictus cell line. Computational Biology and Chemistry 32. 382-386.(PMID: 18706867)
R. Dixit., S. Dixit., Upal Roy, Y. Shouche and S Gakhar.2007. Partial genomic organization of ribosomal protein S7 gene from malaria vector Anopheles stephensi. Insect Science.14. 65-75.DOI: 10.1111/j.1744-7917.2007.00131.
Upal Roy, D Nair.2007. Biodiversity of organotin resistant Pseudomonas from the west coast of India. Ecotoxicology. 16 (2), 253-261. (PMID: 17131180)
T.P. Anand, A. W. Bhat., Y.S. Shouche., Upal Roy, J. Siddharth., S. P. Sharma. 2006. Antimicrobial activity of marine bacteria associated with marine sponges from the waters off the coast of south-east India. Microbiological Research.161. 252-262. (PMID: 16765842).
Upal Roy and S. Bhosle. 2006. Microbial transformation of tributyltin chloride by Pseudomonas aeruginosa strain USS25 NCIM-5224. Applied Organometallic Chemistry.20. 5-11. DOI: 10.1002/aoc.997
Upal Roy; S.K Dubey and S. Bhosle. 2004 Tributyltin chloride degrading bacteria from marine environment of the west coast of India. Current Science.85.702-705.
Upal Roy, S. K. Dubey and S. Bhosle.2001.“Characterisation of Exopolymer Produced by Sphingomonas sp. Utilizing TBTC”. Proceedings of International Conference on Industrial Pollution and Control Technologies (ICIPACT-2001, JNTU, Hyderabad), 639-642.
S.K. Dubey and Upal Roy. 2003 Biodegradation of Tributyltins (organotin) by Marine Bacteria. Applied Organometallic Chemistry.17. 3-8. DOI: 10.1002/aoc.394
Agrawal M, Rathod K, and Roy U. Application of Polymeric Nanoparticles for Brain Targeting. In Application of Nanocarriers in Brain Delivery of Therapeutics, Ed. Amit Alexander. P- 69- 95. Springer. ISBN 978-981-97-2858-9
Roy U and Bekhout, B. HIV Infection and Adipose Tissue-Resident Stem cells: Their Involvement in Pathology and Treatment. In STEM CELLS AND CANCER STEM CELLS: Therapeutic Applications in Disease and Injury, Ed. M.A. Hayat, Kean University, Union, NJ, USA. Springer. Volume 13, 2015. 21-34.
Roy, U., Balkundi, S., McMillan, J., and Gendelman, H.E. Nanomedicine to improve central nervous system drug delivery in neuroAIDS. In: The Neurology of AIDS, Third Edition. Eds: H.E. Gendelman, I.P. Everall, H.S. Fox, H.A. Gelbard, I. Grant, S.A. Lipton, S. Swindells. Oxford University Press, New York, 2011, pp. 987-998.
Roy U and Bhosle S., “Microbial Degradation of Xenobiotics in Marine Environment”, chapter in the book entitled “Advances in Microbiology” Edited by Prof. P.C. Trivedi, Department of Botany, University of Rajasthan, Jaipur-30, India. Published by Scientific Publishers (India), Jodhpur, 2003, p-293-301.